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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
USP14
All Species:
23.94
Human Site:
S369
Identified Species:
35.11
UniProt:
P54578
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P54578
NP_001032411.1
494
56069
S369
E
L
Q
E
K
M
V
S
F
R
S
K
F
K
D
Chimpanzee
Pan troglodytes
P60051
493
55922
S369
E
L
Q
E
K
M
V
S
F
R
S
K
F
K
D
Rhesus Macaque
Macaca mulatta
XP_001090667
458
52239
K338
K
M
V
S
F
R
S
K
F
K
D
L
E
D
K
Dog
Lupus familis
XP_537306
545
61461
S420
E
L
Q
E
K
M
V
S
F
R
S
K
F
K
D
Cat
Felis silvestris
Mouse
Mus musculus
Q9JMA1
493
55983
S369
E
L
Q
E
K
M
V
S
F
R
S
K
F
K
D
Rat
Rattus norvegicus
NP_001008302
493
55958
S369
E
L
Q
E
K
M
I
S
F
R
S
K
F
K
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519267
431
48760
F311
M
V
S
F
R
S
K
F
K
D
L
E
D
K
K
Chicken
Gallus gallus
XP_419150
492
55612
S367
D
L
Q
E
K
M
V
S
Y
R
S
K
F
K
D
Frog
Xenopus laevis
Q6GNI6
523
60030
R365
T
T
L
T
D
C
L
R
R
F
T
R
P
E
H
Zebra Danio
Brachydanio rerio
A6H8I0
506
58102
T374
C
H
S
Y
Q
E
S
T
K
Q
L
T
M
K
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609377
475
53689
L354
T
P
E
L
Q
N
K
L
C
P
M
R
S
K
F
Honey Bee
Apis mellifera
XP_395043
497
56311
P364
E
L
Q
N
K
L
I
P
M
R
E
K
F
K
E
Nematode Worm
Caenorhab. elegans
Q17361
489
55859
I344
L
V
A
R
R
A
D
I
K
L
E
E
D
A
K
Sea Urchin
Strong. purpuratus
XP_786966
516
58357
P370
E
L
Q
E
K
L
V
P
V
R
D
K
F
K
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q949Y0
482
53677
A349
D
L
R
K
K
L
E
A
P
R
Q
K
L
R
E
Baker's Yeast
Sacchar. cerevisiae
P43593
499
57092
K355
E
Y
A
A
E
K
V
K
V
R
D
E
L
R
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
92.5
89.9
N.A.
96.7
96.5
N.A.
80.3
90.4
21.4
20.1
N.A.
54.6
61.7
41.9
61
Protein Similarity:
100
99.8
92.7
90.2
N.A.
98.5
98.7
N.A.
83.8
94.9
39
38.7
N.A.
71.2
80.2
61.1
76.5
P-Site Identity:
100
100
6.6
100
N.A.
100
93.3
N.A.
6.6
86.6
0
6.6
N.A.
6.6
53.3
0
66.6
P-Site Similarity:
100
100
26.6
100
N.A.
100
100
N.A.
26.6
100
26.6
26.6
N.A.
26.6
73.3
20
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.5
26
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
62.9
46.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
26.6
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
73.3
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
13
7
0
7
0
7
0
0
0
0
0
7
0
% A
% Cys:
7
0
0
0
0
7
0
0
7
0
0
0
0
0
0
% C
% Asp:
13
0
0
0
7
0
7
0
0
7
19
0
13
7
38
% D
% Glu:
50
0
7
44
7
7
7
0
0
0
13
19
7
7
19
% E
% Phe:
0
0
0
7
7
0
0
7
38
7
0
0
50
0
7
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
7
% H
% Ile:
0
0
0
0
0
0
13
7
0
0
0
0
0
0
0
% I
% Lys:
7
0
0
7
57
7
13
13
19
7
0
57
0
69
25
% K
% Leu:
7
57
7
7
0
19
7
7
0
7
13
7
13
0
0
% L
% Met:
7
7
0
0
0
38
0
0
7
0
7
0
7
0
0
% M
% Asn:
0
0
0
7
0
7
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
7
0
0
0
0
0
13
7
7
0
0
7
0
0
% P
% Gln:
0
0
50
0
13
0
0
0
0
7
7
0
0
0
0
% Q
% Arg:
0
0
7
7
13
7
0
7
7
63
0
13
0
13
7
% R
% Ser:
0
0
13
7
0
7
13
38
0
0
38
0
7
0
0
% S
% Thr:
13
7
0
7
0
0
0
7
0
0
7
7
0
0
0
% T
% Val:
0
13
7
0
0
0
44
0
13
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
0
7
0
0
0
0
7
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _